Once again, The Kennedy-Mighell Report offers some very simple ways to improve your computer desktop work experience. Easy Productivity Improvements is a thirty-minute podcast that every desk jockey should hear.
If you are working with or comparing more than one document, having multiple monitors is a must. And price is hardly an obstacle. Click here for Microsoft's tips on effective dual monitor setup.
If you have Windows 7, go here for Jim Calloway's advice on how to make two monitors effectively become four monitors.
And if you have to use only one monitor, press ALT-TAB to cycle through all your open programs quickly.
For more keyboard shortcuts, click here for Kennedy's ABA article Quick Cuts: Save Time With a Few Strokes at the Keyboard